Research Studies in RIS/CIS

 

2021

  • Uher T, Krasensky J, Malpas C, Bergsland N, Dwyer MG, Kubala Havrdova E, Vaneckova M, Horakova D, Zivadinov R, Kalincik T (2021) Evolution of Brain Volume Loss Rates in Early Stages of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm 8 [Open article]
  • Uher T, McComb M, Galkin S, Srpova B, Oechtering J, Barro C, Tyblova M, Bergsland N, Krasensky J, Dwyer M, Havrdova EK, Posova H, Vaneckova M, Zivadinov R, Horakova D, Kuhle J, Ramanathan M (2021) Neurofilament levels are associated with blood-brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis. Mult Scler 27:220-231 [Open article]

2020

  • Zivadinov R, Dwyer MG, Carl E, et al. Slowing of brain atrophy with teriflunomide and delayed conversion to clinically definite MS. Ther Adv Neurol Disord 2020;13:1756286420970754. [Open article]
  • Tavazzi E, Bergsland N, Kuhle J, et al. A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis. J Neurol 2020;267:802-811. [Open article]
  • Jakimovski D, Bergsland N, Dwyer MG, et al. Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis. Diagnostics (Basel) 2020;10.

2019

  • Genovese AV, Hagemeier J, Bergsland N, Jakimovski D, Dwyer MG, Ramasamy DP, Lizarraga AA, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2019). "Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis." Radiology 293(2): 424-433. [Open article]
  • Jakimovski D, Weinstock-Guttman B, Gandhi S, Guan Y, Hagemeier J, Ramasamy DP, Fuchs TA, Browne RW, Bergsland N, Dwyer MG, Ramanathan M and Zivadinov R (2019). "Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study." J Neurol 266(4): 866-875. [Open article]

2018

  • Ghione E, Bergsland N, Dwyer MG, Hagemeier J, Jakimovski D, Paunkoski I, Ramasamy DP, Silva D, Carl E, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2018). "Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine." AJNR Am J Neuroradiol 39(12): 2237-2242. [Open article]
  • Dwyer MG, Bergsland N, Ramasamy DP, Jakimovski D, Weinstock-Guttman B and Zivadinov R (2018). "Atrophied Brain Lesion Volume: A New Imaging Biomarker in Multiple Sclerosis." J Neuroimaging 28(5): 490-495. [Open article]
  • Zivadinov R, Ramasamy DP, Hagemeier J, Kolb C, Bergsland N, Schweser F, Dwyer MG, Weinstock-Guttman B and Hojnacki D (2018). "Evaluation of Leptomeningeal Contrast Enhancement Using Pre-and Postcontrast Subtraction 3D-FLAIR Imaging in Multiple Sclerosis." AJNR Am J Neuroradiol 39(4): 642-647. [Open article]
  • Jakimovski D, Kolb C, Ramanathan M, Zivadinov R and Weinstock-Guttman B (2018). "Interferon beta for Multiple Sclerosis." Cold Spring Harb Perspect Med 8(11). [Open article]
  • Schweser F, Raffaini Duarte Martins AL, Hagemeier J, Lin F, Hanspach J, Weinstock-Guttman B, Hametner S, Bergsland N, Dwyer MG and Zivadinov R (2018). "Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: A proposed mechanistic relationship between inflammation and oligodendrocyte vitality." Neuroimage 167: 438-452. [Open article]

2017

  • Uher T, Havrdova E, Sobisek L, Krasensky J, Vaneckova M, Seidl Z, Tyblova M, Ramasamy D, Zivadinov R and Horakova D (2017). "Is no evidence of disease activity an achievable goal in MS patients on intramuscular interferon beta-1a treatment over long-term follow-up?" Mult Scler 23(2): 242-252. [Open article]

2016

  • Schwartz CE, Dwyer MG, Benedict R, Weinstock-Guttman B, Bergsland NP, Li J, Ramanathan M and Zivadinov R (2016). "Reserve-related activities and MRI metrics in multiple sclerosis patients and healthy controls: an observational study." BMC Neurol 16: 108. [Open article]
  • Zivadinov R, Ramasamy DP, Benedict RR, Polak P, Hagemeier J, Magnano C, Dwyer MG, Bergsland N, Bertolino N, Weinstock-Guttman B, Kolb C, Hojnacki D, Utriainen D, Haacke EM and Schweser F (2016). "Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study." Radiology 281(3): 884-895. [Open article]
  • Zivadinov R, Cerza N, Hagemeier J, Carl E, Badgett D, Ramasamy DP, Weinstock-Guttman B and Ramanathan M (2016). "Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS." Neurol Neuroimmunol Neuroinflamm 3(1): e190. [Open article]
  • Uher T, Horakova D, Tyblova M, Zeman D, Krasulova E, Mrazova K, Seidl Z, Vaneckova M, Krasensky J, Weinstock-Guttman B, Ramanathan M, Havrdova E and Zivadinov R (2016). "Increased albumin quotient (QAlb) in patients after first clinical event suggestive of multiple sclerosis is associated with development of brain atrophy and greater disability 48 months later." Mult Scler 22(6): 770-781. [Open article]
  • Kappus N, Weinstock-Guttman B, Hagemeier J, Kennedy C, Melia R, Carl E, Ramasamy DP, Cherneva M, Durfee J, Bergsland N, Dwyer MG, Kolb C, Hojnacki D, Ramanathan M and Zivadinov R (2016). "Cardiovascular risk factors are associated with increased lesion burden and brain atrophy in multiple sclerosis." J Neurol Neurosurg Psychiatry 87(2): 181-187. [Open article]

2015

  • Graziano E, Hagemeier J, Weinstock-Guttman B, Ramasamy DP and Zivadinov R (2015). "Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients." Neuroimage Clin 9: 110-116. [Open article]
  • Schwartz CE, Ayandeh A, Ramanathan M, Benedict R, Dwyer MG, Weinstock-Guttman B and Zivadinov R (2015). "Reserve-building activities in multiple sclerosis patients and healthy controls: a descriptive study." BMC Neurol 15: 135. [Open article]
  • Fellows K, Uher T, Browne RW, Weinstock-Guttman B, Horakova D, Posova H, Vaneckova M, Seidl Z, Krasensky J, Tyblova M, Havrdova E, Zivadinov R and Ramanathan M (2015). "Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients." J Lipid Res 56(10): 2010-2018. [Open article]
  • Varosanec M, Uher T, Horakova D, Hagemeier J, Bergsland N, Tyblova M, Seidl Z, Vaneckova M, Krasensky J, Dwyer MG, Havrdova E and Zivadinov R (2015). "Longitudinal Mixed-Effect Model Analysis of the Association between Global and Tissue-Specific Brain Atrophy and Lesion Accumulation in Patients with Clinically Isolated Syndrome." AJNR Am J Neuroradiol 36(8): 1457-1464. [Open article]
  • Uher T, Horakova D, Kalincik T, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2015). "Early magnetic resonance imaging predictors of clinical progression after 48 months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a." Eur J Neurol 22(7): 1113-1123. [Open article]

2014

  • Uher T, Benedict RH, Horakova D, Bergsland N, Dusankova JB, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment." J Neurol Sci 347(1-2): 229-234. [Open article]
  • Uher T, Horakova D, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "MRI correlates of disability progression in patients with CIS over 48 months." Neuroimage Clin 6: 312-319. [Open article]
  • Uher T, Blahova-Dusankova J, Horakova D, Bergsland N, Tyblova M, Benedict RH, Kalincik T, Ramasamy DP, Seidl Z, Hagermeier J, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome." J Neurol 261(9): 1735-1744. [Open article]
  • Browne RW, Weinstock-Guttman B, Zivadinov R, Horakova D, Bodziak ML, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Qu J, Havrdova E and Ramanathan M (2014). "Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study." J Steroid Biochem Mol Biol 143: 424-433. [Open article]
  • Zivadinov R, Chin J, Horakova D, Bergsland N, Weinstock-Guttman B, Tamano-Blanco M, Badgett D, Hagemeier J, Tyblova M, Carl E, Krasensky J, Vaneckova M, Seidl Z, Dwyer MG, Havrdova E and Ramanathan M (2014). "Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: results from the multi-center set study." J Neuroimmunol 273(1-2): 58-64. [Open article]
  • Hagemeier J, Heininen-Brown M, Gabelic T, Guttuso T, Jr., Silvestri N, Lichter D, Fugoso LE, Bergsland N, Carl E, Geurts JJ, Weinstock-Guttman B and Zivadinov R (2014). "Phase white matter signal abnormalities in patients with clinically isolated syndrome and other neurologic disorders." AJNR Am J Neuroradiol 35(10): 1916-1923. [Open article]
  • Browne RW, Weinstock-Guttman B, Horakova D, Zivadinov R, Bodziak ML, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Havrdova E and Ramanathan M (2014). "Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes." J Neurol Neurosurg Psychiatry 85(8): 859-864. [Open article]
  • Cappellani R, Bergsland N, Weinstock-Guttman B, Kennedy C, Carl E, Ramasamy DP, Hagemeier J, Dwyer MG, Patti F and Zivadinov R (2014). "Diffusion tensor MRI alterations of subcortical deep gray matter in clinically isolated syndrome." J Neurol Sci 338(1-2): 128-134. [Open article]
  • Gabelic T, Ramasamy DP, Weinstock-Guttman B, Hagemeier J, Kennedy C, Melia R, Hojnacki D, Ramanathan M and Zivadinov R (2014). "Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis." AJNR Am J Neuroradiol 35(1): 106-112. [Open article]

2013

  • Weinstock-Guttman B, Horakova D, Zivadinov R, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Havrdova E and Ramanathan M (2013). "Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes." J Neuroimmunol 263(1-2): 121-127. [Open article]
  • Zivadinov R, Havrdova E, Bergsland N, Tyblova M, Hagemeier J, Seidl Z, Dwyer MG, Vaneckova M, Krasensky J, Carl E, Kalincik T and Horakova D (2013). "Thalamic atrophy is associated with development of clinically definite multiple sclerosis." Radiology 268(3): 831-841. [Open article]
  • Weinstock-Guttman B, Zivadinov R, Horakova D, Havrdova E, Qu J, Shyh G, Lakota E, O'Connor K, Badgett D, Tamano-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z and Ramanathan M (2013). "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event." J Neurol Neurosurg Psychiatry 84(11): 1186-1191. [Open article]
  • Horakova D, Zivadinov R, Weinstock-Guttman B, Havrdova E, Qu J, Tamano-Blanco M, Badgett D, Tyblova M, Bergsland N, Hussein S, Willis L, Krasensky J, Vaneckova M, Seidl Z, Lelkova P, Dwyer MG, Zhang M, Yu H, Duan X, Kalincik T and Ramanathan M (2013). "Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study." PLoS One 8(1): e53996. [Open article]
  • Tipirneni A, Weinstock-Guttman B, Ramanathan M, Abdelrahman N, Hussein S, Hagemeier J, Durfee J, Teter BE, Hojnacki D, Dwyer MG and Zivadinov R (2013). "MRI characteristics of familial and sporadic multiple sclerosis patients." Mult Scler 19(9): 1145-1152. [Open article]

2012

  • Magnano C, Schirda C, Weinstock-Guttman B, Wack DS, Lindzen E, Hojnacki D, Bergsland N, Kennedy C, Belov P, Dwyer MG, Poloni GU, Beggs CB and Zivadinov R (2012). "Cine cerebrospinal fluid imaging in multiple sclerosis." J Magn Reson Imaging 36(4): 825-834. [Open article]
  • Bergsland N, Horakova D, Dwyer MG, Dolezal O, Seidl ZK, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2012). "Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis." AJNR Am J Neuroradiol 33(8): 1573-1578. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Magnano C, Hojnacki D, Dwyer MG and Zivadinov R (2012). "Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy." AJNR Am J Neuroradiol 33(8): 1596-1601. [Open article]
  • Hagemeier J, Heininen-Brown M, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Weinstock-Guttman B, Dwyer MG and Zivadinov R (2012). "Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study." J Magn Reson Imaging 36(1): 73-83. [Open article]

2011

  • Horakova D, Zivadinov R, Weinstock-Guttman B, Havrdova E, Tamano-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z, Lelkova P and Ramanathan M (2011). "HLA DRB1*1501 is only modestly associated with lesion burden at the first demyelinating event." J Neuroimmunol 236(1-2): 76-80. [Open article]
  • Zivadinov R, Marr K, Cutter G, Ramanathan M, Benedict RH, Kennedy C, Elfadil M, Yeh AE, Reuther J, Brooks C, Hunt K, Andrews M, Carl E, Dwyer MG, Hojnacki D and Weinstock-Guttman B (2011). "Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS." Neurology 77(2): 138-144. [Open article]

2009

  • Ramasamy DP, Benedict RH, Cox JL, Fritz D, Abdelrahman N, Hussein S, Minagar A, Dwyer MG and Zivadinov R (2009). "Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study." J Neurol Sci 282(1-2): 47-54. [Open article]
  • Antulov R, Weinstock-Guttman B, Cox JL, Hussein S, Durfee J, Caiola C, Dwyer MG, Bergsland N, Abdelrahman N, Stosic M, Hojnacki D, Munschauer FE, Miletic D and Zivadinov R (2009). "Gender-related differences in MS: a study of conventional and nonconventional MRI measures." Mult Scler 15(3): 345-354. [Open article]

2008

  • Zivadinov R, Banas AC, Yella V, Abdelrahman N, Weinstock-Guttman B and Dwyer MG (2008). "Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis." AJNR Am J Neuroradiol 29(2): 319-325. [Open article]

2007

  • Garg N, Zivadinov R, Ramanathan M, Vasiliu I, Locke J, Watts K, Lema J, Rajeswary J, Munschauer FE, Ambrus J, Jr. and Weinstock-Guttman B (2007). "Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients." J Neuroimmunol 187(1-2): 159-165. [Open article]
  • Tavazzi E, Dwyer MG, Weinstock-Guttman B, Lema J, Bastianello S, Bergamaschi R, Cosi V, Benedict RH, Munschauer FE, 3rd and Zivadinov R (2007). "Quantitative diffusion weighted imaging measures in patients with multiple sclerosis." Neuroimage 36(3): 746-754. [Open article]

2006

  • Zivadinov R and Sepcic J (2006). "[Use of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis]." Lijec Vjesn 128(9-10): 295-308. [Open article]