Selected Research Studies on Brain Connectomics and Cognitive Outcomes

2023

  • Jakimovski D, Zivadinov R, Weinstock Z, Fuchs TA, Dwyer MG, Bergsland , Weinstock-Guttman B, Benedict RHB. Cortical thickness and cognitive performance of elderly with multiple sclerosis. J Neurol 2023:doi:10.1007/s00415-023-11945-2. [Open Article]
  • Bartnik A, Fuchs TA, Ashton K, Kuceyeski A, Li X, Mallory M, Oship D, Bergsland N, Ramasamy D, Jakimovski D, Weinstock-Guttman B, Zivadinov R, Dwyer MG. Functional alteration due to structural damage is network dependent: insights from mulyiple sclerosis. Cereb Cortex 2023;33(10):6090-6102. [Open Article]
  • Jakimovski, Kavak KS, Zakalik K, Coetzee T, Gottesman M, Coyle PK, Zivadinov R, Weinstock- Guttman B on behalf of New York State Multiple Sclerosis Consortium (NYSMSC). Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC). Mult Scler 2023;29(6):753-756. [Open Article]
  • Jakimovski D, Wicks T, Bergsland N, Dwyer MG, Weinstock-Guttman B, Zivadinov R. Neuroimaging correlates of patient-reported outcomes in multiple sclerosis. Degener Neurol Neuromuscul Dis 2023;13:21-32. [Open Article]

2022

  • Fuchs TA, Vaughn CB, Benedict RHB, Weinstock-Guttman B, Bergsland N, Jakimovski D, Ramasamy DP, Zivadinov R, Dwyer MG (2022). Patient-reported outcome severity and emotional salience network disruption in multiple sclerosis. Brain Imaging Behav;doi:10.1007/s11682-021-00614-5. [Open article]
  • Weinstock Z, G Morrow S, Conway D, Fuchs T, M,P Wojcik C, Unverdi M, Zivadinov R, Weinstock-Guttman B, Iverson G, Dwyer MG, Benedict RHB. Interpreting change on the Symbol Digit Modalities Test in people with relapsing multiple sclerosis using the reliable change methodology. Mult Scler 2022;28(7):1101-1111. [Open article]
  • Fuchs TA, Schoonheim MM, Broeders TAA, Hulst HE, Weinstock-Guttman B, Jakimovski D,Silver J, Zivadinov R, Geurts JJG, Dwyer MG, Benedict RHB (2021). Functional network dynamics and decreased conscientiousness in multiple sclerosis. J Neurol:doi:10.1007/s00415-021-10860-8. [Open article]
  • Wojcik C, Fuchs TA M,P Tran H, Dwyer MG, Jakimovski D,P Weinstock-Guttman B, Zivadinov R, Eshaghi A, Benedict RHB (2022). Staging and stratifying cognitive dysfunction in multiple sclerosis. Mult Scler;28(3):463-471. [Open article]

2021

  • Weinstock Z, Morrow S, Conway D, Fuchs T, Wojcik C, Unverdi M, Zivadinov R, Weinstock-Guttman B, Iverson GL, Dwyer M, Benedict RH (2021) Interpreting change on the Symbol Digit Modalities Test in people with relapsing multiple sclerosis using the reliable change methodology. Mult Scler:13524585211049397 [Open article]
  • Wojcik C, Jaworski M, 3rd, Dwyer MG, Youngs M, Unverdi M, Weinstock-Guttman B, Benedict RH (2021) Benchmarks of meaningful improvement on neurocognitive tests in multiple sclerosis. Mult Scler:13524585211044672 [Open article]
  • Hildesheim FE, Benedict RHB, Zivadinov R, Dwyer MG, Fuchs T, Jakimovski D, Weinstock-Guttman B, Bergsland N (2021) Nucleus basalis of Meynert damage and cognition in patients with multiple sclerosis. J Neurol [Open Article]
  • Wojcik C, Fuchs TA, Tran H, Dwyer MG, Jakimovski D, Unverdi M, Weinstock-Guttman B, Zivadinov R, Eshaghi A, Benedict RH (2021) Staging and stratifying cognitive dysfunction in multiple sclerosis. Mult Scler:13524585211011390 [Open Article]
  • Jacobsen C, Zivadinov R, Myhr KM, Dalaker TO, Dalen I, Benedict RH, Bergsland N, Farbu E (2021) Brain atrophy and clinical characteristics predicting SDMT performance in multiple sclerosis: A 10-year follow-up study. Mult Scler J Exp Transl Clin 7:2055217321992394 [Open article]
  • Jakimovski D, Benedict RHB, Weinstock-Guttman B, Ozel O, Fuchs TA, Lincoff N, Bergsland N, Dwyer MG, Zivadinov R (2021) Visual deficits and cognitive assessment of multiple sclerosis: confounder, correlate, or both? J Neurol 268:2578-2588 [Open article]
  • Morrow SA, Conway D, Fuchs T, Wojcik C, Unverdi M, Yasin F, Pol J, Eckert S, Hojnacki DH, Dwyer M, Zivadinov R, Weinstock-Guttman B, Benedict RH (2021) Quantifying cognition and fatigue to enhance the sensitivity of the EDSS during relapses. Mult Scler 0:1352458520973618 [Open article]
  • Bergsland N, Benedict RHB, Dwyer MG, Fuchs TA, Jakimovski D, Schweser F, Tavazzi E, Weinstock-Guttman B, Zivadinov R (2021) Thalamic Nuclei Volumes and Their Relationships to Neuroperformance in Multiple Sclerosis: A Cross-Sectional Structural MRI Study. J Magn Reson Imaging 53:731-739 [Open article]
  • Jaworski MG, 3rd, Fuchs TA, Dwyer MG, Wojcik C, Zivadinov R, Weinstock-Guttman B, Benedict RH (2021) Conscientiousness and deterioration in employment status in multiple sclerosis over 3 years. Mult Scler:1352458520946019 [Open article]
  • Ashton K, Fuchs TA, Oship D, Zivadinov R, Jakimovski D, Bergsland N, Ramasamy DP, Vaughn C, Weinstock-Guttman B, Benedict RHB, Dwyer MG (2021) Diagnosis of depression in multiple sclerosis is predicted by frontal-parietal white matter tract disruption. J Neurol 268:169-177 [Open article]
  • Benedict RH, Pol J, Yasin F, Hojnacki D, Kolb C, Eckert S, Tacca B, Drake A, Wojcik C, Morrow SA, Jakimovski D, Fuchs TA, Dwyer MG, Zivadinov R, Weinstock-Guttman B (2021) Recovery of cognitive function after relapse in multiple sclerosis. Mult Scler 27:71-78 [Open article]

2020

  • Morrow SA, Conway D, Fuchs T, Wojcik C, Unverdi M, Yasin F, Pol J, Eckert S, Hojnacki DH, Dwyer M, Zivadinov R, Weinstock-Guttman B, Benedict RH. Quantifying cognition and fatigue to enhance the sensitivity of the EDSS during relapses. Mult Scler. 2020 Dec 1:1352458520973618. [Open article]
  • Jaworski MG 3rd, Fuchs TA, Dwyer MG, Wojcik C, Zivadinov R, Weinstock-Guttman B, Benedict RH. Conscientiousness and deterioration in employment status in multiple sclerosis over 3 years. Mult Scler. 2020 Aug 6:1352458520946019. [Open article]
  • Jakimovski D, Szigeti K, Jaworski M 3rd, Ouf A, Weinstock-Guttman B, Zivadinov R, Benedict RHB. Differential Diagnosis of Cognitive Decline in Elderly Individuals With Multiple Sclerosis. Cogn Behav Neurol. 2020 Dec;33(4):294-300. [Open article]
  • Fuchs TA, Ziccardi S, Benedict RHB, Bartnik A, Kuceyeski A, Charvet LE, Oship D, Weinstock-Guttman B, Wojcik C, Hojnacki D, Kolb C, Escobar J, Campbell R, Tran HD, Bergsland N, Jakimovski D, Zivadinov R, Dwyer MG. Functional Connectivity and Structural Disruption in the Default-Mode Network Predicts Cognitive Rehabilitation Outcomes in Multiple Sclerosis. J Neuroimaging. 2020 Jul;30(4):523-530. [Open article]
  • Fuchs TA, Wojcik C, Wilding GE, Pol J, Dwyer MG, Weinstock-Guttman B, Zivadinov R, Benedict RH. Trait Conscientiousness predicts rate of longitudinal SDMT decline in multiple sclerosis. Mult Scler. 2020 Feb;26(2):245-252. [Open article]
  • Fuchs TA, Benedict RH, Wilding G, Wojcik C, Jakimovski D, Bergsland N, Ramasamy DP, Weinstock-Guttman B, Zivadinov R, Dwyer MG. Trait Conscientiousness predicts rate of brain atrophy in multiple sclerosis. Mult Scler. 2020 Oct;26(11):1433-1436. [Open article]

2019

  • Jakimovski D, Weinstock-Guttman B, Roy S, Jaworski M, 3rd, Hancock L, Nizinski A, Srinivasan P, Fuchs TA, Szigeti K, Zivadinov R and Benedict RHB (2019). "Cognitive Profiles of Aging in Multiple Sclerosis." Front Aging Neurosci 11: 105. [Open article]
  • Fuchs TA, Ziccardi S, Dwyer MG, Charvet LE, Bartnik A, Campbell R, Escobar J, Hojnacki D, Kolb C, Oship D, Pol J, Shaw MT, Wojcik C, Yasin F, Weinstock-Guttman B, Zivadinov R and Benedict RHB (2019). "Response heterogeneity to home-based restorative cognitive rehabilitation in multiple sclerosis: An exploratory study." Mult Scler Relat Disord 34: 103-111. [Open article]
  • Fuchs TA, Vaughn CB, Benedict RHB, Weinstock-Guttman B, Choudhery S, Carolus K, Rooney P, Ashton K, D PR, Jakimovski D, Zivadinov R and Dwyer MG (2019). "Lower self-report fatigue in multiple sclerosis is associated with localized white matter tract disruption between amygdala, temporal pole, insula, and other connected structures." Mult Scler Relat Disord 27: 298-304. [Open article]
  • Fuchs TA, Benedict RHB, Bartnik A, Choudhery S, Li X, Mallory M, Oship D, Yasin F, Ashton K, Jakimovski D, Bergsland N, Ramasamy DP, Weinstock-Guttman B, Zivadinov R and Dwyer MG (2019). "Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis." Hum Brain Mapp 40(18): 5231-5241. [Open article]
  • Deshpande HU, Mellis AM, Lisinski JM, Stein JS, Koffarnus MN, Paluch R, Schweser F, Zivadinov R, LaConte SM, Epstein LH and Bickel WK (2019). "Reinforcer pathology: Common neural substrates for delay discounting and snack purchasing in prediabetics." Brain Cogn 132: 80-88. [Open article]

2018

  • Zivadinov R (2018). "Why Is Cognitive Impairment Present in Multiple Sclerosis? Insights from Functional MRI." Radiology 288(2): 552-553. [Open article]
  • Willer BS, Zivadinov R, Haider MN, Miecznikowski JC and Leddy JJ (2018). "A Preliminary Study of Early-Onset Dementia of Former Professional Football and Hockey Players." J Head Trauma Rehabil 33(5): E1-E8. [Open article]
  • Roy S, Drake AS, Eizaguirre MB, Zivadinov R, Weinstock-Guttman B, Chapman BP and Benedict RH (2018). "Trait neuroticism, extraversion, and conscientiousness in multiple sclerosis: Link to cognitive impairment?" Mult Scler 24(2): 205-213. [Open article]
  • Roy S, Drake A, Snyder S, Cline B, Khan A, Fuchs T, Zivadinov R, Weinstock-Guttman B, Szigeti K and Benedict RHB (2018). "Preliminary investigation of cognitive function in aged multiple sclerosis patients: Challenges in detecting comorbid Alzheimer's disease." Mult Scler Relat Disord 22: 52-56. [Open article]
  • Roy S, Drake A, Fuchs T, Dwyer MG, Zivadinov R, Chapman BP, Weinstock-Guttman B and Benedict RH (2018). "Longitudinal personality change associated with cognitive decline in multiple sclerosis." Mult Scler: 1352458517753720. [Open article]
  • Jakimovski D, Weinstock-Guttman B, Hagemeier J, Vaughn CB, Kavak KS, Gandhi S, Bennett SE, Fuchs TA, Bergsland N, Dwyer MG, Benedict RHB and Zivadinov R (2018). "Walking disability measures in multiple sclerosis patients: Correlations with MRI-derived global and microstructural damage." J Neurol Sci 393: 128-134. [Open article]
  • Fuchs TA, Dwyer MG, Kuceyeski A, Choudhery S, Carolus K, Li X, Mallory M, Weinstock-Guttman B, Jakimovski D, Ramasamy D, Zivadinov R and Benedict RHB (2018). "White matter tract network disruption explains reduced conscientiousness in multiple sclerosis." Hum Brain Mapp 39(9): 3682-3690. [Open article]
  • Fuchs TA, Carolus K, Benedict RHB, Bergsland N, Ramasamy D, Jakimovski D, Weinstock-Guttman B, Kuceyeski A, Zivadinov R and Dwyer MG (2018). "Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study." AJNR Am J Neuroradiol 39(8): 1480-1486. [Open article]

2017

  • Roy S, Frndak S, Drake AS, Irwin L, Zivadinov R, Weinstock-Guttman B and Benedict RH (2017). "Differential effects of aging on motor and cognitive functioning in multiple sclerosis." Mult Scler 23(10): 1385-1393. [Open article]

2016

  • Zivadinov R, Raj B, Ramanathan M, Teter B, Durfee J, Dwyer MG, Bergsland N, Kolb C, Hojnacki D, Benedict RH and Weinstock-Guttman B (2016). "Autoimmune Comorbidities Are Associated with Brain Injury in Multiple Sclerosis." AJNR Am J Neuroradiol 37(6): 1010-1016. [Open article]
  • Schwartz CE, Dwyer MG, Benedict R, Weinstock-Guttman B, Bergsland NP, Li J, Ramanathan M and Zivadinov R (2016). "Reserve-related activities and MRI metrics in multiple sclerosis patients and healthy controls: an observational study." BMC Neurol 16: 108. [Open article]
  • Roy S, Schwartz CE, Duberstein P, Dwyer MG, Zivadinov R, Bergsland N, Powell V, Weinstock-Guttman B and Benedict RH (2016). "Synergistic Effects of Reserve and Adaptive Personality in Multiple Sclerosis." J Int Neuropsychol Soc: 1-8. [Open article]
  • Roy S, Rodgers J, Drake AS, Zivadinov R, Weinstock-Guttman B and Benedict RH (2016). "Stable neuropsychiatric status in multiple sclerosis: a 3-year study." Mult Scler 22(4): 569-574. [Open article]

2015

  • Schwartz CE, Ayandeh A, Ramanathan M, Benedict R, Dwyer MG, Weinstock-Guttman B and Zivadinov R (2015). "Reserve-building activities in multiple sclerosis patients and healthy controls: a descriptive study." BMC Neurol 15: 135. [Open article]
  • Mak E, Dwyer MG, Ramasamy DP, Au WL, Tan LC, Zivadinov R and Kandiah N (2015). "White Matter Hyperintensities and Mild Cognitive Impairment in Parkinson's Disease." J Neuroimaging 25(5): 754-760. [Open article]
  • Kavak KS, Teter BE, Hagemeier J, Zakalik K, Weinstock-Guttman B and New York State Multiple Sclerosis C (2015). "Higher weight in adolescence and young adulthood is associated with an earlier age at multiple sclerosis onset." Mult Scler 21(7): 858-865. [Open article]
  • Graziano E, Hagemeier J, Weinstock-Guttman B, Ramasamy DP and Zivadinov R (2015). "Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients." Neuroimage Clin 9: 110-116. [Open article]

2014

  • Uher T, Blahova-Dusankova J, Horakova D, Bergsland N, Tyblova M, Benedict RH, Kalincik T, Ramasamy DP, Seidl Z, Hagermeier J, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome." J Neurol 261(9): 1735-1744. [Open article]
  • Pfordresher PQ, Mantell JT, Brown S, Zivadinov R and Cox JL (2014). "Brain responses to altered auditory feedback during musical keyboard production: an fMRI study." Brain Res 1556: 28-37. [Open article]
  • Mak E, Bergsland N, Dwyer MG, Zivadinov R and Kandiah N (2014). "Subcortical atrophy is associated with cognitive impairment in mild Parkinson disease: a combined investigation of volumetric changes, cortical thickness, and vertex-based shape analysis." AJNR Am J Neuroradiol 35(12): 2257-2264. [Open article]
  • Donohue K, Cox JL, Dwyer MG, Aliotta R, Corwin M, Weinstock-Guttman B, Ann Yeh E and Zivadinov R (2014). "No regional gray matter atrophy differences between pediatric- and adult-onset relapsing-remitting multiple sclerosis." J Neuroimaging 24(1): 63-67. [Open article]
  • Benedict RH, Morrow S, Rodgers J, Hojnacki D, Bucello MA, Zivadinov R and Weinstock-Guttman B (2014). "Characterizing cognitive function during relapse in multiple sclerosis." Mult Scler 20(13): 1745-1752. [Open article]

2013

  • Tipirneni A, Weinstock-Guttman B, Ramanathan M, Abdelrahman N, Hussein S, Hagemeier J, Durfee J, Teter BE, Hojnacki D, Dwyer MG and Zivadinov R (2013). "MRI characteristics of familial and sporadic multiple sclerosis patients." Mult Scler 19(9): 1145-1152. [Open article]
  • Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttmann B, Yeh A, Rodriguez M, Ness J, Gorman M, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N and Zivadinov R (2013). "Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study." BMC Neurol 13(1): 173. [Open article]
  • Booth AJ, Rodgers JD, Schwartz CE, Quaranto BR, Weinstock-Guttman B, Zivadinov R and Benedict RH (2013). "Active Cognitive Reserve Influences the Regional Atrophy to Cognition Link in Multiple Sclerosis." J Int Neuropsychol Soc: 1-6. [Open article]
  • Benedict RH, Schwartz CE, Duberstein P, Healy B, Hoogs M, Bergsland N, Dwyer MG, Weinstock-Guttman B and Zivadinov R (2013). "Influence of personality on the relationship between gray matter volume and neuropsychiatric symptoms in multiple sclerosis." Psychosom Med 75(3): 253-261. [Open article]

2011

  • Dalaker TO, Zivadinov R, Ramasamy DP, Beyer MK, Alves G, Bronnick KS, Tysnes OB, Aarsland D and Larsen JP (2011). "Ventricular enlargement and mild cognitive impairment in early Parkinson's disease." Mov Disord 26(2): 297-301. [Open article]
  • Covey TJ, Zivadinov R, Shucard JL and Shucard DW (2011). "Information processing speed, neural efficiency, and working memory performance in multiple sclerosis: differential relationships with structural magnetic resonance imaging." J Clin Exp Neuropsychol 33(10): 1129-1145. [Open article]
  • Benedict RH and Zivadinov R (2011). "Risk factors for and management of cognitive dysfunction in multiple sclerosis." Nat Rev Neurol 7(6): 332-342. [Open article]

2009

  • Di Perri C, Dalaker TO, Beyer MK and Zivadinov R (2009). "Neuroimaging of cognitive impairments in vascular disease." Int Rev Neurobiol 84: 49-80. [Open article]
  • Dalaker TO, Larsen JP, Dwyer MG, Aarsland D, Beyer MK, Alves G, Bronnick K, Tysnes OB and Zivadinov R (2009). "White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson's disease." Neuroimage 47(4): 2083-2089. [Open article]
  • Benedict RH, Ramasamy D, Munschauer F, Weinstock-Guttman B and Zivadinov R (2009). "Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy." J Neurol Neurosurg Psychiatry 80(2): 201-206. [Open article]

2008

  • Benedict RH, Shucard JL, Zivadinov R and Shucard DW (2008). "Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis." Neuropsychol Rev 18(2): 149-166. [Open article]
  • Benedict RH, Hussein S, Englert J, Dwyer MG, Abdelrahman N, Cox JL, Munschauer FE, Weinstock-Guttman B and Zivadinov R (2008). "Cortical atrophy and personality in multiple sclerosis." Neuropsychology 22(4): 432-441. [Open article]

2007

  • Tekok-Kilic A, Benedict RH, Weinstock-Guttman B, Dwyer MG, Carone D, Srinivasaraghavan B, Yella V, Abdelrahman N, Munschauer F, Bakshi R and Zivadinov R (2007). "Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis." Neuroimage 36(4): 1294-1300. [Open article]
  • Benedict RH, Bruce J, Dwyer MG, Weinstock-Guttman B, Tjoa C, Tavazzi E, Munschauer FE and Zivadinov R (2007). "Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis." Mult Scler 13(6): 722-730. [Open article]

2006

  • Tekok-Kilic A, Benedict RH and Zivadinov R (2006). "Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis." Expert Rev Neurother 6(3): 323-331. [Open article]
  • Carone DA, Benedict RH, Zivadinov R, Singh B and Ambrus JL (2006). "Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder." J Neuroimaging 16(2): 163-166. [Open article]
  • Carone DA, Benedict RH, Dwyer MG, Cookfair DL, Srinivasaraghavan B, Tjoa CW and Zivadinov R (2006). "Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS." Neuroimage 29(2): 505-514. [Open article]
  • Benedict RH and Zivadinov R (2006). "Predicting neuropsychological abnormalities in multiple sclerosis." J Neurol Sci 245(1-2): 67-72. [Open article]
  • Benedict RH, Bruce JM, Dwyer MG, Abdelrahman N, Hussein S, Weinstock-Guttman B, Garg N, Munschauer F and Zivadinov R (2006). "Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis." Arch Neurol 63(9): 1301-1306. [Open article]

2004

  • Zivadinov R and Sepcic J (2004). "[Cognitive impairment in multiple sclerosis patients]." Lijec Vjesn 126(7-8): 204-210. [Open article]